RT Journal Article
SR Electronic
T1 Calculating the individual probability of successful ocriplasmin treatment in eyes with VMT syndrome: a multivariable prediction model from the EXPORT study
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 1092
OP 1097
DO 10.1136/bjophthalmol-2017-310874
VO 102
IS 8
A1 Paul, Christoph
A1 Heun, Christine
A1 Müller, Hans-Helge
A1 Hoerauf, Hans
A1 Feltgen, Nicolas
A1 Wachtlin, Joachim
A1 Kaymak, Hakan
A1 Mennel, Stefan
A1 Koss, Michael Janusz
A1 Fauser, Sascha
A1 Maier, Mathias M
A1 Schumann, Ricarda G
A1 Mueller, Simone
A1 Chang, Petrus
A1 Schmitz-Valckenberg, Steffen
A1 Kazerounian, Sara
A1 Szurman, Peter
A1 Lommatzsch, Albrecht
A1 Bertelmann, Thomas
YR 2018
UL http://bjo.bmj.com/content/102/8/1092.abstract
AB Background/Aims To evaluate predictive factors for the treatment success of ocriplasmin and to use these factors to generate a multivariate model to calculate the individual probability of successful treatment.Methods Data were collected in a retrospective, multicentre cohort study. Patients with vitreomacular traction (VMT) syndrome without a full-thickness macular hole were included if they received an intravitreal injection (IVI) of ocriplasmin. Five factors (age, gender, lens status, presence of epiretinal membrane (ERM) formation and horizontal diameter of VMT) were assessed on their association with VMT resolution. A multivariable logistic regression model was employed to further analyse these factors and calculate the individual probability of successful treatment.Results 167 eyes of 167 patients were included. Univariate analysis revealed a significant correlation to VMT resolution for all analysed factors: age (years) (OR 0.9208; 95% CI 0.8845 to 0.9586; p<0.0001), gender (male) (OR 0.480; 95% CI 0.241 to 0.957; p=0.0371), lens status (phakic) (OR 2.042; 95% CI 1.054 to 3.958; p=0.0344), ERM formation (present) (OR 0.384; 95% CI 0.179 to 0.821; p=0.0136) and horizontal VMT diameter (µm) (OR 0.99812; 95% CI 0.99684 to 0.99941, p=0.0042). A significant multivariable logistic regression model was established with age and VMT diameter.Conclusion Known predictive factors for VMT resolution after ocriplasmin IVI were confirmed in our study. We were able to combine them into a formula, ultimately allowing the calculation of an individual probability of treatment success with ocriplasmin in patients with VMT syndrome without FTHM.