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Abstract
Aims To assess the association between statin use and cataract surgery according to different statin treatment durations in patients with different cardiovascular risk profiles.
Methods and results We performed a nested case–control study using Danish registries, covering the period from 1 January 1996 to 31 December 2020. We defined cases as surgically treated cataract patients, matched in a 1:1 ratio by sex and age with controls not undergoing cataract surgery. The exposure of interest was statin use in different durations (1, 5 and 10 years) compared with never use of statins. Conditional logistic regression provided adjusted HRs and corresponding 95% CIs in subgroups defined by established atherosclerotic cardiovascular disease, diabetes, hypertension and individuals without these comorbidities. We identified 505 150 cataract surgery cases and found no increased HR of cataract surgery with statin treatment at any duration in any of the subgroups with established atherosclerotic cardiovascular disease, diabetes or hypertension.
Conclusion Our findings do not support a possible association between long-term statin use and cataract in patients with established atherosclerotic cardiovascular disease, diabetes or hypertension. Although we found an association between statin use and cataract in individuals without these comorbidities, increasing durations of statin use did not yield higher cataract surgery rates.
- Epidemiology
- Inflammation
- Lens and zonules
- Pharmacology
- Treatment Surgery
Data availability statement
Data are available on reasonable request. We are able to provide the data used for conducting the present study on reasonable request as this requires special access to Statistics Denmark.
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Data availability statement
Data are available on reasonable request. We are able to provide the data used for conducting the present study on reasonable request as this requires special access to Statistics Denmark.
Footnotes
Contributors AH, CNB and CT-P made substantial contributions to the conception or design of the work. AH, SH, BZ, TEE, KKS, CL-A, CNB and CT-P each contributed significantly to the acquisition, analysis or interpretation of data for the work. AH, SH, BZ, TEE, KKS, CL-A, CNB and CT-P each contributed significantly in the drafting the work and revising it critically for important intellectual content. Finally, AH, SH, BZ, TEE, KKS, CL-A, CNB and CT-P each made the final approval of the version to be published; and all authors are in agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. AH is the guarantor of the study.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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