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Editor,—The use of postoperative subconjunctival 5-fluorouracil (5-FU) injection to inhibit scarring after glaucoma filtering surgery is now commonplace. Uncomplicated subconjunctival 5-FU injection is unlikely to produce endothelial toxicity, as post-injection anterior chamber drug levels remain low.1However, inadvertent intraocular exposure can be toxic to the cornea.2 We report a case of postoperative subconjunctival 5-FU injection with accidental passage of the drug directly into the anterior chamber.
CASE REPORT
A left trabeculectomy was performed on a 79 year old white woman using peroperative 5-FU (25 mg/ml). Two days later the patient rubbed her eye and the anterior chamber became transiently flat. Over the next 4 weeks the drainage bleb encysted, and the patient received 5 mg (0.2 ml) 5-FU into the superior bulbar conjunctiva. Immediately after injection the intraocular pressure (IOP) …